Two new papers in October!

Papers, papers, papers!

The lab is on fire and published two new papers in October! Congratulations to all!

In the first paper, Maia and Ellen used focused CRISPR screens and toxin-based sensors to determine that Smoothened activation and hedgehog signaling are driven by a biochemically-defined, small fraction of accessible cholesterol. Interested? Read more about it here in eLIFE.

In the second paper, Broder uses a combination of bioinformatic analysis and quantitative live-cell reporter assays for TDP43 phase separation and splicing function to uncover the rules that link the amino acid sequence of TDP43 with its phase properties and to show that phase separation-deficient TDP43 mutants unexpectedly can still function in splicing. Want to see more of his great images? Check it out here in Nature Communications.